Regulation of human L-histidine decarboxylase gene expression
نویسندگان
چکیده
منابع مشابه
The regulation of histidine decarboxylase gene expression.
Histamine is a biogenic amine, which is involved in a variety of biologic processes comprising inflammation, allergic responses, neurotransmission and regulation of gastric acid secretion. The key enzyme for the generation of histamine is histidine decarboxylase (HDC), which converts the amino acid L-histidine to histamine. In this article, we review the history, biochemistry and molecular biol...
متن کاملControl of histidine decarboxylase gene expression in enterochromaffin-like cells.
The ability of histamine to stimulate gastric acid secretion was recognized over 75 years ago by Popielski [1]. The central importance of this action in the physiological regulation of acid secretion was established with the development of histamine H2 receptor antagonists by Black and colleagues in the early 1970s [2]. There has, however, been intense debate about the precise mechanisms of act...
متن کاملMast cell-/basophil-specific transcriptional regulation of human L-histidine decarboxylase gene by CpG methylation in the promoter region.
L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils. We attempted here to discover how HDC gene expression is restricted in these cells. In the cultured cell lines tested, only the mast cells and basophils strongly transcribed the HDC gene. However, in transient transfect...
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We have studied the regulation of the expression of ornithine decarboxylase with the aid of transgenic mice harbouring either functional human ornithine decarboxylase genes or the mouse ornithine decarboxylase promoter-driven chloramphenicol acetyltransferase fusion gene in their genome. We used three different stimuli which are well known to enhance ornithine decarboxylase activity in their ap...
متن کاملChapter 6 L - Histidine Decarboxylase A Marker of Histaminergic Neurons
The role of histamine (HA) as a neurotransmitter in the CNS, although proposed a decade ago (Schwartz, 1975), has been only progressively recognized (reviewed by Schwartz et al., 1980, 1982, 1984; Hough and Green, 1984). One of the key pieces of expenmental evidence has been the demonstration that synthesis of the amine in CNS depends on a specific enzyme, L-histidine decarboxylase (HDC) (Schwa...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)37565-1